The FAA Removing an Old Rule to Allow Pilots Treatment for Depression. Will This Impair Their Job Performance? In the past pilots were not allowed to take any form of anti-depressant. This rule was created for the safety of the passengers. Some side effects of anti-depressants would inhibit a pilot’s ability to perform their job. Insomnia, Diarrhea, dizziness, fatigue, drowsiness, tremors, increased perspiration, abdominal pain, vision changes, and hot flashes, are just several of the many possible side effects of an anti-depressant. Regulators were most concerned about the dizziness, drowsiness, fatigue, and vision changes when creating this safety rule.